Mouse LRRC32&TGF-beta 1 Heterotrimer protein, His Tag&Tag Free (MALS verified)

GARP (LRRC32) is a transmembrane protein that binds latent-TGF-£]1 and tethers it on the Treg surface. and has been proved to promote the activation and secretion of transforming growth factor £] (TGF-£]). The expression of GARP is highly on the surface activated Tregs and increases the suppressive function of Tregs. Additionally, GARP can bind to latent transforming growth factor £] (TGF-£]), thus promoting secretion and activation of TGF-£]. TGF-£] plays a critical rule for homeostasis and function of Tregs. Notably, it has been also observed that fibroblasts and endothelial cell lines that express GARP/latent TGF-£]1 complexes do not activate TGF-£]1. However, it cannot be excluded that specific stimuli are required to trigger TGF-£]1 activation from complexes on the surface of these cell types.