Mouse LILRB4 / CD85k / ILT3 Protein, Fc Tag

Source : 

Mouse LILRB4, Fc Tag (CDK-M5250) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Lys 238 (Accession # Q64281-1).

 

Molecule : LILRB4

 

Synonyms : LILRB4,ILT3,LIR5,CD85K,HM18

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_038560.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. As a result of glycosylation, the protein migrates as 60-66 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-P

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

 

References :

(1) Cella M., et al., 1997, J. Exp. Med. 185:1743-1751.
(2) Chang C.C., et al., 2002, Nat. Immunol. 3:237-243.