Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free

Source : 

Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (IT8-M52W6) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 (ITGAV) & Gly 22 - Leu 681 (ITGB8) (Accession # P43406-1 (ITGAV) & Q0VBD0-1 (ITGB8)).

 

Molecule : Integrin alpha V beta 8

 

Synonyms : Integrin alpha V beta 8,ITGAV&ITGB8

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_032428.2 (ITGAV) & NP_796264.2 (ITGB8)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 112.5 kDa (ITGAV) & 77.5 kDa (ITGB8)

 

Characteristics :

Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB8, has a calculated MW of 112.5 kDa (ITGAV) and 77.5 kDa (ITGB8). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistid

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.

 

References :

(1) Moyle, M. et al., 1991, J. Biol. Chem. 266:19650-8.
(2) Nishimura SL., et al., 1994, J Biol Chem. 269(46):28708-15.
(3) Araya, J. et al., 2006, Am. J. Pathol. 169:405-15.
(4) Mu,D.et al.,2002, J. Cell Biol.157:493-507.