Mouse IL-3 R alpha / CD123 Protein, His Tag (SPR verified)

Source : 

Mouse IL-3 R alpha, His Tag (ILA-M52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 17- Lys 331 (Accession # P26952-1).

 

Molecule : IL-3 R alpha

 

Synonyms : IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_032395.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 36.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.4 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

 

References :

(1) Mardiros A., et al. 2013, Blood., 122(18), 3138-48.
(2) Rapoport AP., et al. 1996, Blood., 87(1), 112-22.
(3) Klöß S., et al. 1996, Hum Gene Ther., 28(10), 897-913.