Mouse IL-17A / CTLA-8 Protein, His Tag (MALS verified)

Source : 

Mouse IL-17A, His Tag (CT8-M5240) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Ala 158 (Accession # Q62386-1).

 

Molecule : IL-17A

 

Synonyms : IL-17A,Interleukin-17A,CTLA-8,IL-17

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : NP_034682.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 15.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 15.8 kDa. The protein migrates as 18 kDa, 20-23 kDa and 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

 

References :

(1) Yao Z., et al.,1995, J. Immunol. 155:5483-5486.
(2) Gerhardt S., et al., 2009, J. Mol. Biol. 394:905-921.