Mouse gp130 / CD130 / IL-6 R beta Protein, His Tag

Source : 

Mouse gp130, His Tag (ILT-M52H1) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Glu 617 (Accession # NP_034690).

 

Molecule : gp130

 

Synonyms : IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_034690

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 68.5 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 68.5 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

 

References :

(1) Saito M., et al., 1992, J. Immunol. 148:4066-4071.
(2) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
(3) Tanaka M., et al., 1999, Blood 93:804-815.