Mouse GITR / TNFRSF18 Protein, His Tag

Source : 

Mouse GITR, His Tag (GIR-M5220) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - His 153 (Accession # Q8C4K3).

 

Molecule : GITR

 

Synonyms : AITR,GITR,TNFRSF18,CD357

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 15.5 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.5 kDa. The protein migrates as 27-34 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

 

References :

(1) Gurney A.L., et al., 1999, Curr. Biol. 9:215-218.
(2) Park MS., et al., 2007, Yonsei Med J 48 (5): 839-46.