Mouse Fc gamma RIV / CD16-2 Protein, His Tag

Source : 

Mouse CD16-2, His Tag (FC4-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Gln 203 (Accession # A0A0B4J1G0-1).

 

Molecule : Fc gamma RIV / CD16-2

 

Synonyms : Fc gamma RIV,CD16-2,Fcgr4

 

Format : Powder

 

Category : MABSol® Fc Receptors

 

Accession : NP_653142.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 22.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

FcgR4(Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma . Also acts as a receptor for the Fc region of immunoglobulin epsilon . Binds with intermediate affinity to both IgG2a and IgG2b . Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions

 

References :

(1) Hirano M, et al. 2007. Nat Immunol. 8(7):762-71.
(2) Mancardi DA. 2008. J Clin Invest. 118(11):3738-50.
(3) Nimmerjahn F. 2005. Immunity. 23(1):41-51.