Mouse CD38 Protein, His Tag

Source : 

Mouse CD38, His Tag (CD8-M5223) is expressed from human 293 cells (HEK293). It contains AA Leu 45 - Thr 304 (Accession # P56528-1).

 

Molecule : CD38

 

Synonyms : CD38,T10,cADPr hydrolase 1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_031672.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 31.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.7 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM MES, 100 mM NaCl, pH6.5

 

Description :

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

 

References :

(1) Orciani M., et al., 2008, J. Cell. Biochem. 105 (3): 905–12.
(2) Nata K., et al., 1997, Gene 186 (2): 285–92.
(3) Malavasi F., et al., 2008, Physiol. Rev. 88 (3): 841–86.