Mouse CCL6 / C10 Protein, His Tag

Source : 

Mouse CCL6, His Tag (CC6-M5222) is expressed from human 293 cells (HEK293). It contains AA Gly 22 - Ala 116 (Accession # P27784).

 

Molecule : CCL6

 

Synonyms : CCL6,SCYA6,C10,MRP-1

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 11.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11.7 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Chemokine (C-C motif) ligand 6 (CCL6), a member of the CC chemokine family, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM­CSF. CCL6 has only been identified in rodents, A human homologue for mouse CCL6 has not been identified.  The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, where it is strongly induced upon GM­CSF (Cat. # GMF-H4214) stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 (Cat. # IL4-H4218) in mouse macrophages and by cytokine IL­13 (Cat. # IL3-H4210) in mouse lung. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.

 

References :

(1) Orlofsky, et al., 1991, Cell Regul. 2 (5), 403-412.
(2) Ma., et al., 2004, J Immunol.172(3):1872-81.
(3) Berger., et al., 1993, DNA Cell Biol. 12 (9), 839-847.
(4) Kanno M, et al., 2005, J Neuroimmunol. 167(1-2): 72-80.