Mouse B7-1 / CD80 Protein, His Tag

B7-1 and B7-2, together with their receptors CD28 and CTLA?4, constitute one of the dominant co-stimulatory pathways that regulate T? and B?cell responses. Although both CTLA?4 and CD28 can bind to the same ligands, CTLA?4 binds to B7?1 and B7?2 with a 20 ? 100 fold higher affinity than CD28 and is involved in the down?regulation of the immune response.
B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-£eB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.