Monoclonal antibody to human neuronal acetylcholine receptor subunit alpha-4 [4E3]: IgG
Antibodies
- 貨號 Cat. No.
- M-815-100
- 規格 Size
- 100 µg
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
CHRNA4
Antibody_Isotype
(Antibody only) :
Application_Details :
This antibody is recommended for WB and direct ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) : 4E3
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=294
Description (Long Description) :
Neuronal acetylcholine receptor is composed of alpha and beta subunits. The Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Upon binding of acetylcholine, the acetylcholine receptor responds by undergoing an extensive change of conformation affecting all its subunits and lead to the opening of an ion-conducting channel across the plasma membrane. Neuronal acetylcholine receptor subunit alpha-4 is a transmembrane protein that localises to the cell junction, synapse and post synaptic cell membrane. It belongs to the ligand-gated ionic channel family. Abnormalities in the CHRNA4 gene cause autosomal dominant nocturnal frontal lobe epilepsy type 1. This disease is characterised by clusters of motor seizures during sleep.
Expiry_Date :
12 months after purchase
Format (Form) :
Lyophilized from PBS pH 7.2
Immunogen (Antigen) :This antibody was raised against a partial recombinant protein of human neuronal acetylcholine receptor subunit alpha-4 (amino acids 29 to 128) with a GST tag.
Kit_Components :
MSDS (File name) :
