Monoamine Oxidase B (MAO-B) Inhibitor Screening Kit (Fluorometric)

Alternate Name :

Tag Line :

Only kit on the market to screen monoamine oxidase B (MAO-B) inhibitors

Storage Conditions: -20°C

Shelf life: 12 months

Summary :

• Detection method: Fluorescence (Ex/Em = 535/587 nm)
• Application:
Screening/studying/characterizing MAO-B inhibitors

Detection Method: Fluorescence (Ex/Em = 535/587 nm)

Features & Benefits:

• Rapid & sensitive
• High-throughput assay to screen/study/characterize potential inhibitors of monoamine oxidase B
• Includes Inhibitor Control [Selegiline]

Description:

Monoamine oxidases (MAO, EC 1.4.3.4) are a family of enzymes that can oxidize a wide variety of endogenous primary amines. Two isoforms, MAO-A and MAO-B, have been identified based on their substrate, inhibitor specificity, and tissue localization. MAO-B can oxidize primary amines, but its list of specific substrates (i.e. benzylamine, phenylethylamine) is more limited compared to MAO-A. MAO-B is a mitochondrial-bound enzyme that is ubiquitously expressed throughout the brain and other tissues. It has been investigated in numerous studies including Parkinson’s disease, Alzheimer’s, and tobacco addiction. Specific MAO-B inhibitors such as selegiline, & rasagiline have been used to treat Parkinson’s patients, but their benefits are considered rather modest. BioVision’s MAO-B Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of MAO-B inhibitors. The assay is based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO substrate.