Monoamine Oxidase A (MAO-A) Inhibitor Screening Kit (Fluorometric)

Alternate Name :

Tag Line :

Only kit on the market to screen monoamine oxidase A (MAO-A) inhibitors

Storage Conditions: -20°C

Shelf life: 12 months

Summary :

• Detection method: Fluorescence (Ex/Em = 535/587 nm)
• Application:
Screening/studying/characterizing MAO-A inhibitors

Detection Method: Fluorescence (Ex/Em = 535/587 nm)

Features & Benefits:

• Rapid & sensitive
• High-throughput assay to screen/study/characterize potential inhibitors of monoamine oxidase A
• Includes Inhibitor Control [Clorgyline]

Description:

Monoamine oxidases (MAO, EC 1.4.3.4) are a family of enzymes that can oxidize a wide variety of endogenous primary amines. Two isoforms, MAO-A and MAO-B, have been identified based on their substrate, inhibitor specificity, and tissue localization. MAO-A can oxidize primary amines such as serotonin and norepinephrine. MAO-A is a mitochondrial-bound enzyme that is ubiquitously expressed throughout the brain and other tissues. It has been implicated in panic, anxiety, and depression. Several MAO-A specific inhibitors such as clorgyline, brofaromine, toloxatone, tetrindole, etc. have been used as antidepressants, but their usage has been limited due to side effects. BioVision’s MAO-A Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of MAO-A inhibitors. The assay is based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO substrate.