MOG [35-55] Peptide (Rat)

Myelin-oligodendrocyte glycoprotein (MOG) is a minor component of the myelin sheath. MOG is also a CNS-specific autoantigen for primary demyelination in multiple sclerosis. The developmentally late expression of MOG correlates with the later stages of myelogenesis, suggesting that MOG has a role in the completion, compaction and maintenance of myelin. MOG has many isoforms that can form homo- and heterodimers. It has been shown that the MOG [35-55] peptide induced anti-MOG (35-55) autoantibody production in C57BL/6 mice with 100% incident (10/10), providing quantitative support for the suitability of the MOG peptide for in vivo anti-MOG (35-55) autoantibody study.