MMP-2 Antibody

h1 class=titleMMP-2 Antibody/h1
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h4Catalog Number/h4
pstrong250752/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pMatrix metalloproteinase protein family (MMP) is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in diseases such as arthritis and metastasis. Most MMPs are secreted as inactive precursors which are activated upon cleavage by extracellular proteinases. MMP-2 is an enzyme that degrades gelatin type I and collagen types IV, V, VII and X, and KiSS1. MMP-2 is also a ligand for the integrin alpha-V/beta-3. Defects in MMP-2 are the cause of multicentric osteolysis nodulosis and arthropathy (MONA), and Winchester syndrome, both characterized by excessive destruction and resorption of bones./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
p72 kDa type IV collagenase; 72 kDa gelatinase; Matrix metalloproteinase-2; MMP-2; Gelatinase A; TBE-1; MMP2; CLG4A/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P08253P08253/abr /
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h4Clonality/h4
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h4Antigen/h4
pnbsp;/p
pKLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MMP-2./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R | Other/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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