MMP-12 Antibody
- 貨號 Cat. No.
- 3532R-100
- 規格 Size
- 100 µg
Description
pstrongAntibody Target :/strongMMP-12/p
pbHost: /bRabbit/p
pbAntibody Type: /bPolyclonal/p
pbIsotype: /bRabbit IgG/p
pbAntibody Form: /bAffinity Purified Antibody/p
pbImmunogen Sequence: /bSynthetic peptide surrounding amino acid 460 of human MMP-12/p
pbAccession#: /bNP_002417/p
pbGene ID: /b4321/p
pbAppearance: /bColorless liquid/p
pbConcentration: /b0.2 mg/ml/p
pbFormulation: /b100 micro;g (0.2 mg/ml) protein A purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal./p
pbPurification: /bAffinity purified/p
pbSpecies Reactivity: /bhu/ms/p
pbApplication: /bWB/IP/IHC/p
pbApplication amp; Usage: /bWestern blotting (1-4 micro;g/ml). However, the optimal concentrations should be determined individually.The antibody recognizes a ~50 kDa band from samples of human origin. Reactivity to other species has not been tested. Jurkat cell lysate (Cat.# 2401-100) can be used as a positive control./p
pbStorage Temp.: /b-20 deg;C/p
pbShipping : /bgel pack/p
pbShelf Life: /b12 months/p
pbHandling: /bThe antibody solution should be gently mixed before use./p
pbBrief Background Descriptions: /bThe matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders./p
pbHost: /bRabbit/p
pbAntibody Type: /bPolyclonal/p
pbIsotype: /bRabbit IgG/p
pbAntibody Form: /bAffinity Purified Antibody/p
pbImmunogen Sequence: /bSynthetic peptide surrounding amino acid 460 of human MMP-12/p
pbAccession#: /bNP_002417/p
pbGene ID: /b4321/p
pbAppearance: /bColorless liquid/p
pbConcentration: /b0.2 mg/ml/p
pbFormulation: /b100 micro;g (0.2 mg/ml) protein A purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal./p
pbPurification: /bAffinity purified/p
pbSpecies Reactivity: /bhu/ms/p
pbApplication: /bWB/IP/IHC/p
pbApplication amp; Usage: /bWestern blotting (1-4 micro;g/ml). However, the optimal concentrations should be determined individually.The antibody recognizes a ~50 kDa band from samples of human origin. Reactivity to other species has not been tested. Jurkat cell lysate (Cat.# 2401-100) can be used as a positive control./p
pbStorage Temp.: /b-20 deg;C/p
pbShipping : /bgel pack/p
pbShelf Life: /b12 months/p
pbHandling: /bThe antibody solution should be gently mixed before use./p
pbBrief Background Descriptions: /bThe matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders./p