MMP-11 Polyclonal Ab

貨號 Cat. No.
3531-100
規格 Size
100 ug

Description

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pfont size=2bHOST:/b Rabbit /font/p
pfont size=2bIMMUNOGEN:/b Synthetic peptide mapping to the hinge region of human MMP-11 /font/p
pfont size=2bFORMULATION: /b100 ug (0.5 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal. /font/p
pfont size=2bSPECIES REACTIVITY: /bhuman, mouse, rat /font/p
pfont size=2bSTORAGE CONDITIONS: /bStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles. /font/p
pfont size=2bBACKGROUND: /bThe matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies. /font/p
pfont size=2bSPECIFICITY: /bThe antibody recognizes the latent (~64 kDa) and the active forms (30-55 kDa) of MMP-11 from human, mouse, and rat origins. /font/p
pfont size=2bAPPLICATION: /bThe antibody can be used in Western blotting (1-4 ug/ml), immunoprecipitation (10-20 ug/ml), and immunohistochemistry (15-25 ug/ml). However, the optimal concentrations should be determined individually. USAGE: For Research Use Only. Not to be used in humans. /font/p
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