ML323
Chemical Compounds
- 貨號 Cat. No.
- M3721
- 規格 Size
- 5mg,10mg
- 品牌 Brand
- No Brand
Description
ML323 is a highly potent inhibitor of the USP1-UAF1 deubiquitinase complex with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases. ML323 potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells. ML323 and related N-benzyl-2-phenylpyrimidin-4-amine derivatives possess nanomolar USP1/UAF1 inhibitory potency.
