ML133 hydrochloride

ML133 hydrochloride is a potent K(ir)2.1 inhibitor, which inhibits K(ir)2.1 with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 but exhibits little selectivity against other members of Kir2.x family channels. ML133 hydrochloride has no effect on K(ir)1.1 (IC50 > 300 μM) and displays weak activity for K(ir)4.1 (76 μM) and K(ir)7.1 (33 μM). ML133 HCl also displays modest selectivity versus hERG and possesses fair ancillary pharmacology against a larger panel of GPCRs, ion channels and transporters.