Mitoxantrone dihydrochloride

Mitoxantrone dihydrochloride is a potent type II DNA topoisomerase inhibitor. Mitoxantrone dihydrochloride disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells, by intercalation. Mitoxantrone dihydrochloride increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone dihydrochloride also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.