Mitoxantrone

貨號 Cat. No.: S1889
規格 Size: 50mg~300mg
品牌 Brand: Selleckchem

Description

Mitoxantrone

Catalog No.S1889

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively

Size

Price

Stock

Quantity

50mg	USD 63	In stock	0 1 2 3 4 5 6 7 8 9 10
100mg	USD 100	In stock	0 1 2 3 4 5 6 7 8 9 10
300mg	USD 214	In stock	0 1 2 3 4 5 6 7 8 9 10

Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw

Biological Activity

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 µM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is an anthracenedione (not an anthracycline) antineoplastic agent. It disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin’s lymphoma. It was also shown to improve the survival of children suffering from first relapse of acute lymphoblastic leukaemia. It also engages in intercalation. ^[1][2][3]

Chemical Information

Molecular Weight (MW)	444.48
Formula	C₂₂H₂₈N₄O₆
CAS No.	70476-82-3

Storage	3 years -20â„ƒPowder
Storage	6 months-80â„ƒin DMSO
Syonnyms	Novantrone

Solubility (25°C) *	In vitro	DMSO	89 mg/mL (200 mM)
		Water	<1 mg/mL (<1 mM)
		Ethanol	<1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.