mIL-6
- 貨號 Cat. No.
- I-220
- 規格 Size
- 5 μg 5x5 μg
Description
mIL-6
mouse Interleukin-6
| Product#: | I-220 |
| Sizes: |
| 5 μg |
| 5 x 5 μg |
Interleukin-6 (IL-6) is a cytokine involved in a wide variety of biological functions.
It plays an essential role in the final differentiation of B-cells into immunoglobulin-secreting
cells,1,2 nerve cell differentiation and it stimulates hepatocytes to produce acute-phase
proteins such as C-reactive protein (CRP), fibrinogen and serum amyloid A protein.3,4
IL-6 and IL-3 synergize in vitro to promote the proliferation of multipotent hematopoietic
progenitor cells.5,6 In murine bone marrow cultures, IL-6 shows activities resembling those
of GM-CSF. IL-6 is also a thrombopoietin that induces the maturation of megakaryocytes in vitro
and increases platelet counts in vivo.7,8
IL-6 promotes survival of cholinergic neurons in culture, and some neuronal cell lines can be induced
to differentiate by IL-6.9-11
IL-6 is produced by various types of lymphoid and non-lymphoid cells, such as T cells, B cells,
monocytes, fibroblasts, endothelial cells, and several tumor cells.12 It induces growth of T cells
and differentiation of cytotoxic T cells.13 IL-6 acts synergistically with IL-3 to support the
formation of multilineage blast cell colonies in hematopoiesis. It also induces differentiation
of macrophages, megakaryocytes and osteoclasts.14
| Preparation: |
| mIL-6 is a recombinant neuropoietic cytokine produced in E. coli. |
| M.W.: |
| 21.7 kDa (187 amino acid residues). |
| Purity: |
| Greater than 98% as estimated by SDS-PAGE analysis. |
| Bioassay: |
| The activity was determined by the dose-dependent stimulation of the proliferation of IL-6-dependent mouse 7TD1 cells. The ED50 in this assay was found to be > 0.02 ng/ml. |
| Locus Link ID: | 16193 mouse Interleukin-6. |
| References: |
1. | Rieckmann, P. et al. (1997) Methods 11, 128. |
2. | Horn, F. et al. (2000) Immunobiology 202, 151. |
3. | Ramadori, G. et al. (1990) Z. Gastroenterol. 28, 14. |
4. | Heinrich, P.C. et al. (1998) Z. Ernahrungswiss. 37 Suppl 1, 43. |
5. | Ruscetti, F.W. (1994) Curr. Opin. Hematol. 1, 210. |
6. | Hawley, R.G. (1994) Stem Cells 12 Suppl 1, 155. |
7. | Williams, N. et al. (1992) Ciba Found. Symp. 167, 160. |
8. | Burstein, S.A. (1994) Stem Cells 12, 386. |
9. | Taga, T. (1992) Nippon. Rinsho. 50, 1802. |
10. | Juttler, E. et al. (2002) Neuroscientist 8, 268. |
11. | Gruol, D.L. et al. (1997) Mol. Neurobiol. 15, 307. |
12. | Zhong, H. et al. (1996) Zhonghua Wai Ke Za Zhi 34, 22. |
13. | Quentmeier, H. et al. (1992) J. Immunol. 149, 3316. |
14. | Naka, T. et al. (2002) Arthritis Res. 4 Suppl 3, S233 |