mGluR-7 (E894) Antibody

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h3 class=list6_t1Host: Rabbit/h3
h3 class=list6_t1Reactivity: Human,Mouse,Rat/h3
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h3 class=list6_t1Product/h3
p class=list6_text1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2./p
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h3 class=list6_t1Purification amp; Purity/h3
p class=list6_textThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is gt; 95% (by SDS-PAGE)./p
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h3 class=list6_t1Specificity/h3
p class=list6_textmGluR7 (E894) antibody detects endogenous levels of mGluR7 protein./p
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h3 class=list6_t1Applications (Recommended Dilutions)/h3
p class=list6_textWB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200/p
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h3Western Blot(WB)/h3
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div style=width: 250pxWestern blot (WB) analysis of mGluR7 (E894) antibody in extracts from HuvEc cells./div
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h3Immunohistochemistry (IHC)/h3
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pImmunohistochemistry (IHC) analyzes of mGluR7 (E894) antibody in paraffin-embedded human brain tissue./p
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h3 class=list6_t1Storageamp;Stability/h3
p class=list6_textStore at 4deg;C short term. Aliquot and store at -20deg;C long term. Avoid freeze-thaw cycles./p
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h3 class=list6_t1Background/h3
p class=list6_textThe mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-7, which can interact with PRKCABP, acts as a receptor for glutamate. It is highly expressed in various areas of the brain, but highest levels are detected in cerebellum, cerebral cortex and hippocampus./p
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