Mechlorethamine HCl

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h1 itemprop=name style=margin: 0px 20px 0px 0px; padding: 0px; font-size: 24px; float: left;Mechlorethamine HCl/h1
div class=product_c_title style=margin: 0px 20px 0px 0px; padding: 0px; height: 25px; float: left;span class=p_title style=margin: 0px 15px 0px 0px; padding: 0px; float: left;Catalog No.S4252/span/div
p class=new_title style=margin: 5px 0px 10px; padding: 0px; clear: both; font-size: 11px; line-height: 14.399999618530273px;Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication./p
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td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;50mg/label/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 122/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
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h3 id=biologicalActivity style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Biological Activity/h3
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th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Description/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication./td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Targets/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);IC50/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vitro/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Mechlorethamine is much less toxic to rat hepatocytes under nitrogen and causes much less lipid peroxidation than under aerobic conditions.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/mechlorethamine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/spannbsp;Mechlorethamine markedly inhibits cell growth and leads to cell detachment associated with rearrangement of the cytoskeletal proteins in rabbit tracheal primary cultures. Mechlorethamine results in early lipid peroxidation and cellular membrane damage in rabbit tracheal primary cultures, this is correlated with a significant increase in the activities of antioxidant enzymes associated with an increase in glutathione content.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/mechlorethamine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[2]/a/span/td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vivo/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Mechlorethamine (1.5 mg/kg i.v.) reduces mean leukocyte count from 6,320 mmspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;3/spannbsp;to 1,890 mmspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;3/spannbsp;without any change in the leukocyte differential or erythrocyte and platelet counts in rabbits.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/mechlorethamine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[3]/a/spannbsp;Mechlorethamine (0.005 mg-0.5 mg, i.d.) causes dose-dependent skin ulcers in the mouse, and isotonic sodium thiosulfate (0.167 M) or hypertonic (0.34 M) (0.05 mL) given immediately after Mechlorethamine significantly reduces the mean HN2 ulceration area and the total time of ulceration.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/mechlorethamine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[4]/a/span/td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Features/th
td colspan=6 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
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h4 class=reference margin_t style=margin: 10px 0px 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;References/h4
h3 id=chemicalInformation style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Chemical Information/h3
pa href=http://file.selleckchem.com/downloads/product-sdf/Mechlorethamine-HCl-s4252.SDF style=margin: -25px 0px 0px 180px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; float: left;Download Mechlorethamine HCl SDF/a/p
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th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Molecular Weight (MW)/th
td width=55% style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);192.51/td
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th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Formula/th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);
p style=margin: 0px; padding: 0px;Cspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;5/spanHspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;11/spanClspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;2/spanN.HCl/p
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th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);CAS No./th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);55-86-7/td
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th rowspan=2 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Storage/th
td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);3 yearsnbsp;span class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-20℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;Powder/span/td
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td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);6 monthsspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-80℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;in DMSO/span/td
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th width=161 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Syonnyms/th
td width=214 class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);N/A/td
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th width=12% rowspan=3 style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);strong style=margin: 0px; padding: 0px;Solubility (25deg;C)nbsp;/strongspan class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/span/th
td width=10% rowspan=3 class=italic style=margin: 0px; padding: 5px 15px; font-style: italic; border-style: solid; border-color: rgb(229, 229, 229);In vitro/td
td width=50% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);DMSO/td
td width=28% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);39 mg/mL (202 mM)/td
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td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Water/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);39 mg/mL (202 mM)/td
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td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Ethanol/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);39 mg/mL (202 mM)/td
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td colspan=4 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;lt;1 mg/ml means slightly soluble or insoluble.br style=margin: 0px; padding: 0px; /
span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations./td
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th width=153px style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Chemical Name/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Ethanamine-1,2-13C2, 2-chloro-N-(2-chloroethyl-1,2-13C2)-N-methyl-, hydrochloride (1:1)/td
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div class=counter style=margin: 10px 0px 0px; padding: 0px; font-size: 14px; font-weight: bold; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;a href=http://www.selleckchem.com/molaritycalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Molarity Calculator/anbsp;a href=http://www.selleckchem.com/dilutioncalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Dilution Calculator/anbsp;a href=http://www.selleckchem.com/molecular-weight-calculator.html style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Molecular Weight Calculator/a/div
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h2 style=margin: 0px 0px 10px; padding: 0px; border-bottom-width: 2px; border-bottom-style: solid; border-bottom-color: rgb(53, 87, 148); font-size: 12px; height: 23px;span style=margin: 0px; padding: 4px 15px 2px; display: inline-block; color: rgb(255, 255, 255); background: rgb(53, 87, 148);Customers Who Bought This Item Also Bought/span/h2
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p class=cont style=margin: 3px 0px 0px; padding: 0px; width: 209px; height: 55px; overflow: hidden; color: rgb(102, 102, 102);Axitinib is a multi-target inhibitor ofb style=margin: 0px; padding: 0px;VEGFR1/b,nbsp;b style=margin: 0px; padding: 0px;VEGFR2/b,nbsp;b style=margin: 0px; padding: 0px;VEGFR3/b, PDGFRbeta; and c-Kit withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively./p
p class=p2 style=margin: 0px; padding: 0px; width: 209px; height: 50px; color: rgb(102, 102, 102); line-height: 16.200000762939453px; overflow: hidden;span style=margin: 0px 3px 0px 0px; padding: 0px; color: rgb(255, 120, 0); font-weight: bold;Features:/spanSuperior as second-line therapy relative to sorafenib (current standard-of-care)./p
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li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Clofarabine.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Clofarabine/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Clofarabine inhibits the enzymatic activities ofnbsp;b style=margin: 0px; padding: 0px;ribonucleotide reductase/b(b style=margin: 0px; padding: 0px;IC50/bnbsp;= 65 nM) and DNA polymerase./p
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li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Cytarabine(Cytosar-U).html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Cytarabine/a
p class=cont style=margin: 3px 0px 0px; padding: 0px; width: 209px; height: 55px; overflow: hidden; color: rgb(102, 102, 102);Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent andb style=margin: 0px; padding: 0px;DNA synthesis/bnbsp;inhibitor withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;of 16 nM in wild-type CCRF-CEM cells./p
p class=p2 style=margin: 0px; padding: 0px; width: 209px; height: 50px; color: rgb(102, 102, 102); line-height: 16.200000762939453px; overflow: hidden;span style=margin: 0px 3px 0px 0px; padding: 0px; color: rgb(255, 120, 0); font-weight: bold;Features:/spanThe 1st of a series of cancer drugs that alters the sugar component of nucleosides./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Bortezomib.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Bortezomib (PS-341)/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Bortezomib (PS-341) is a potentnbsp;b style=margin: 0px; padding: 0px;20S proteasome/bnbsp;inhibitor withnbsp;b style=margin: 0px; padding: 0px;Kspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;i/span/bnbsp;of 0.6 nM./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Eloxatin.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Oxaliplatin/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Oxaliplatin inhibits DNA synthesis by conforming DNA adducts./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Busulfan(Busulfex).html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Busulfan/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Busulfan is a cell cycle non-specific alkylating antineoplastic agent./p
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