Antibodies
(+)-Matrine
- 貨號 Cat. No.
- S2322
- 規格 Size
- 100mgã€200mgã€500mg
- 品牌 Brand
- Selleckchem
Description
(+)-Matrine
Catalog No.S2322
Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. | |||||
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| In vitro | Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. [1]matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice. [2] | |||||
| In vivo | LD50: Mice 157mg/kg (i.p.) [3] | |||||
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Protocol(Only for Reference)
References
Chemical Information
| Molecular Weight (MW) | 248.36 |
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| Formula | C15H24N2O |
| CAS No. | 519-02-8 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | (+)-Matrine |
| Chemical Name |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
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| Mass(mg) | 0.24836 | 2.4836 | 4.9672 | 7.4508 |
Tech Support & FAQs
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
