Mannan-binding Lectin (3B6) Antibody

h1 class=titleMannan-binding Lectin (3B6) Antibody/h1
div id=node-553 class=node ntype-antibodiesMouse Monoclonal
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h4Catalog Number/h4
pstrong250353/strong/p
h4Unit/h4
pstrong0.2 mg /strong/p
h4Format/h4
pEach vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography./p
pnbsp;/p
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h4Description/h4
pMannan-binding lectin (MBL), also called mannose-binding lectin or protein, belongs to the C-type family of collectins, showing calcium-dependent binding to certain sugars. It consists of oligomers of triple-chain subunits and its binding and complement activating activities depend on its normal oligomerization. On binding to mannan-like microbial surface carbohydrates, MBL activates the complement system by means of its own lectin pathway, dependent on the MBL-associated serine proteases (MASPs). Because of the presence of different structural and promoter alleles in the population, 12% or more of the population have low concentrations (lt;50ng/mL) of normally oligomerized, functional MBL in plasma or serum. This antibody is specific for MBL from human serum or plasma./p
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h4Product Citations/h4
pnbsp;/p
h4Recommended Products/h4
pa href=http://abbiotec.com/antibodies/mannan-binding-lectin-%2811c9%29-antibody250355 Mannan-binding Lectin (11C9) Antibody/abr /
a href=http://abbiotec.com/antibodies/mannan-binding-lectin-%281e2%29-antibody250354 Mannan-binding Lectin (1E2) Antibody/abr /
nbsp;/p
h4Alternate Names/h4
pMannose-binding protein C;nbsp; MBP-C;nbsp; MBP1;nbsp; Mannose-binding lectin; mannan-binding protein; MBL2; MBL/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/P11226P11226/abr /
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h4Clonality/h4
p3B6/p
h4Antigen/h4
pnbsp;/p
pMBL purified from human donor plasma and adsorbed onto aluminum hydroxide/p
pnbsp;/p
h4Application Notes/h4
pnbsp;/p
pProduct Cat. No. 250353 is selective for normally oligomerized MBL when used as both capture and detection antibody in sandwich ELISA. Product Cat. No. 250353 reacts in western blot with human MBL in oligomerized state and as single protein chain of 26 kDa. Product Cat. No. 250353 is also used for immunohistochemistry on frozen or paraffin-embedded human liver and brain tissue samples./p
pE: 1:20,000/p
pWB: 1:1,000/p
pIHC: 1:500/p
pstrongReacts with/strongnbsp; :H/p
pnbsp;/p
h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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