Mafenide acetate

Mafenide Acetate is used to treat severe burns. Mafenide acetate is a topical agent used routinely for these patients, but it has some disadvantages including painful application and allergic rash. 5% mafenide acetate/amphotericin B (2 mcg/ml) solution, applied to excised and grafted burn wounds, does not produce clinically relevant serum levels of amphotericin B. In honey-dressed wounds, early subsidence of acute inflammatory changes, better control of infection, and quicker wound healing were observed, while in mafenide acetate treated wounds a sustained inflammatory reaction was noted even on epithelialization.