MADD Polyclonal Ab
- 貨號 Cat. No.
- 3066-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= /nbsp;/p
pfont size=2strongHOST: /strongRabbitbr /
br /
strongIMMUNOGEN: /strongSynthetic peptide surrounding amino acid 1573 of human MADDbr /
br /
strongFORMULATION: br /
/strong100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-MADD polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.br /
br /
strongSPECIES REACTIVITY:/strong human, mousebr /
br /
strongSTORAGE CONDITIONS: br /
/strongStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles.br /
br /
strongBACKGROUND DESCRIPTION: br /
/strongMAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein through their death domains. Over expression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98% identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94% overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87% identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNF-R1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNF-R1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.br /
strongbr /
APPLICATION AND USAGE: br /
/strongThe antibody can be used for Western blot analysis (1-4 ug/ml) and immunohistochemistry (10-40 ug/ml). However, the optimal conditions should be determined individually. br /
br /
strongFOR RESEARCH USE ONLY! Not to be used in human.br /
/strong/font/p
pfont size=2strongHOST: /strongRabbitbr /
br /
strongIMMUNOGEN: /strongSynthetic peptide surrounding amino acid 1573 of human MADDbr /
br /
strongFORMULATION: br /
/strong100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-MADD polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.br /
br /
strongSPECIES REACTIVITY:/strong human, mousebr /
br /
strongSTORAGE CONDITIONS: br /
/strongStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles.br /
br /
strongBACKGROUND DESCRIPTION: br /
/strongMAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein through their death domains. Over expression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98% identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94% overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87% identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNF-R1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNF-R1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.br /
strongbr /
APPLICATION AND USAGE: br /
/strongThe antibody can be used for Western blot analysis (1-4 ug/ml) and immunohistochemistry (10-40 ug/ml). However, the optimal conditions should be determined individually. br /
br /
strongFOR RESEARCH USE ONLY! Not to be used in human.br /
/strong/font/p