LY310762

LY310762 is a potent and selective 5-HT1D serotonin receptor antagonist with an EC50 of 31 nM for the guinea pig 5-HT1D receptor. LY310762 had a higher affinity for the guinea pig 5-HT1D receptor (Ki=31 nM) than for the 5-HT1B receptor (Ki>1000 nM). LY310762 exhibited no activity on 5-HT transport. In microdialysis studies, injection of either LY310762 at 10 mg/kg by the intraperitoneal (i.p.) route, potentiated the increase in extracellular 5-HT concentration produced by a maximally effective dose of the selective serotonin re-uptake inhibitor, fluoxetine (at 20 mg/kg i.p.).LY310762 potentiated the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 values of 31 nM.