LRP-5/6 Antibody
- 貨號 Cat. No.
- 3801-100
- 規格 Size
- 100 µg
Description
pstrongAntibody Target :/strongLRP-5/6/p
pbHost: /bMouse/p
pbAntibody Type: /bMonoclonal/p
pbIsotype: /bMouse IgG2bk/p
pbAntibody Form: /bAffinity Purified Antibody/p
pbImmunogen Sequence: /bSynthetic peptide derived from human LRP-6/p
pbAccession#: /bO75197/p
pbGene ID: /b4041/p
pbAppearance: /bColorless liquid/p
pbConcentration: /b1.0 mg/ml/p
pbFormulation: /b100 micro;g (1 mg/ml) purified antibody in 10 mM Tris-glycine (pH 7.0), 0.15 M NaCl, 25% glycerol, 0.5% BSA, and 0.01% sodium azide./p
pbPurification: /bAffinity purified/p
pbSpecies Reactivity: /bhu/ms/p
pbApplication: /bWB/p
pbApplication amp; Usage: /bWestern blot analysis (1-2 micro;g/ml). However, the optimal conditions should be determined individually. Detects full length and a proteolytic fragment of LRP-6./p
pbStorage Temp.: /b-20 deg;C/p
pbShipping : /bgel pack/p
pbShelf Life: /b12 months/p
pbHandling: /bThe antibody solution should be gently mixed before use./p
pbBrief Background Descriptions: /bLDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin, leading Axin degradation and beta;-catenin stabilization./p
pbHost: /bMouse/p
pbAntibody Type: /bMonoclonal/p
pbIsotype: /bMouse IgG2bk/p
pbAntibody Form: /bAffinity Purified Antibody/p
pbImmunogen Sequence: /bSynthetic peptide derived from human LRP-6/p
pbAccession#: /bO75197/p
pbGene ID: /b4041/p
pbAppearance: /bColorless liquid/p
pbConcentration: /b1.0 mg/ml/p
pbFormulation: /b100 micro;g (1 mg/ml) purified antibody in 10 mM Tris-glycine (pH 7.0), 0.15 M NaCl, 25% glycerol, 0.5% BSA, and 0.01% sodium azide./p
pbPurification: /bAffinity purified/p
pbSpecies Reactivity: /bhu/ms/p
pbApplication: /bWB/p
pbApplication amp; Usage: /bWestern blot analysis (1-2 micro;g/ml). However, the optimal conditions should be determined individually. Detects full length and a proteolytic fragment of LRP-6./p
pbStorage Temp.: /b-20 deg;C/p
pbShipping : /bgel pack/p
pbShelf Life: /b12 months/p
pbHandling: /bThe antibody solution should be gently mixed before use./p
pbBrief Background Descriptions: /bLDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin, leading Axin degradation and beta;-catenin stabilization./p