LIF Protein, Mouse, Recombinant

Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to
the IL-6 family of cytokines. It’s involved in growth promotion and cell
differentiation of different types of target cells, influence on bone
metabolism, cachexia, neural development, embryogenesis and
inflammation. LIF has potent proinflammatory property, being the inducer
of the acute phase protein synthesis and affecting the cell recruitment into
the area of damage or inflammation. LIF is also one of the cytokines that
are capable to regulate the differentiation of embryonic stem cells,
hematopoietic and neuronal cells. LIF binds to the specific LIF receptor
(LIFR-α) which forms a heterodimer with a specific subunit common to all
members of that family of receptors, the GP130 signal transducing subunit.
This leads to activation of the JAK/STAT and MAPK cascades. Due to its
polyfunctional activities, LIF is involved in the pathogenic events and
development of many diseases of various origin.