LEPR Antibody

The leptin receptor (LEP-R, CD295) is the receptor for leptin (obesity factor). The binding of leptin mediates signaling through JAK2/STAT3 pathway resulting in the regulation of fat metabolism and, in hematopoietic cells, lymphopoiesis. LEP-R forms a homodimer upon leptin binding, and the phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3.