Lactacystin (Synthetic)

Appearance: White solid

Formulation: N/A

CAS Number: 133343-34-7

Molecular Formula: C₁₅H₂₄N₂O₇S

Molecular Weight: 376.42

Purity: ≥95% by HPLC

Solubility: DMSO (25 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (ICâ‚…â‚€ = 10 µM).

Handling: Protect from air and moisture