Lactacystin
- 貨號 Cat. No.
- I-116
- 規格 Size
- 1 mg
- 品牌 Brand
- Boston Biochem
Description
Lactacystin
synthetic
Product Information
1 mg
376.4
98% by HPLC. Structure confirmed by 1H-NMR.
Soluble and stable in DMSO or MeCN up to 20 mg/ml. Pellet dry compound prior to DMSO addition. Subject to hydrolysis in aqueous buffers.
kobs/[I] = 4,000 M-1 s-1 vs. 20S:PA28 complex.
Inhibits ubiquitin proteasome pathway in cell culture (IC50=10 μM).
Use & Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Catalog #: I-116
Lactacystin
Product Source:
synthetic
Potent, highly specific, irreversible and cell-permeable inhibitor that covalently modifies the catalytic β subunits (chymotrypsin-, trypsin- and caspase-like activities) of the proteasome. Lactacystin is hydrolyzed in aqueous solutions to a clasto-lactacystin β-lactone intermediate which is the active inhibitory species that reacts with the proteasome.
Product Information
Quantity:
1 mg
FW:
376.4
Structure:
Purity:
98% by HPLC. Structure confirmed by 1H-NMR.
Solubility:
Soluble and stable in DMSO or MeCN up to 20 mg/ml. Pellet dry compound prior to DMSO addition. Subject to hydrolysis in aqueous buffers.
Activity:
kobs/[I] = 4,000 M-1 s-1 vs. 20S:PA28 complex.
Inhibits ubiquitin proteasome pathway in cell culture (IC50=10 μM).
Use & Storage
Storage:
Store at -20°C. Avoid multiple freeze/thaw cycles.