Kits
L-Citrulline photometric
Kits
Description
Nitric oxide (NO) is an intra- and intercellular signaling molecule. It reacts with free
radicals, metalloproteins and specific amino acid residues of proteins. NO plays an
important role in the regulation of vascular tone. Endothelial NO (eNO) is produced
by the vascular endothelium. It diffuses to neighboring vascular smooth muscle cells
(VSMC), where NO activates soluble guanylate cyclase (sGC), which subsequently increases
the intracellular cGMP production from GTP, and which in turn causes relaxation
of smooth muscle and vasodilatation.
Thus, functional changes of the endothelium in coronary artery disease may be an
important factor in the development of vasospasm, ischaemia and thrombosis.
radicals, metalloproteins and specific amino acid residues of proteins. NO plays an
important role in the regulation of vascular tone. Endothelial NO (eNO) is produced
by the vascular endothelium. It diffuses to neighboring vascular smooth muscle cells
(VSMC), where NO activates soluble guanylate cyclase (sGC), which subsequently increases
the intracellular cGMP production from GTP, and which in turn causes relaxation
of smooth muscle and vasodilatation.
Thus, functional changes of the endothelium in coronary artery disease may be an
important factor in the development of vasospasm, ischaemia and thrombosis.