L-685, 458
- 貨號 Cat. No.
- 1713-250
- 規格 Size
- 250 µg
Description
Alternate Name/Synonyms: 5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-( 2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide
Appearance: Liquid
Formulation: 1 mM solution in DMSO (250 µg in 372 µl)
CAS Number: 292632-98-5
Molecular Formula: C₃₉H₅₂N₄O₆
Molecular Weight: 672.85
Purity: ≥98% by HPLC
Solubility: N/A
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: Cell-permeable. A potent and selective γ-secretase inhibitor (ICâ‚…â‚€ = 17 nM) .Displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (ICâ‚…â‚€ values are 48 and 67 nM respectively in human neuroblastoma cells).
Handling: Protect from air and light