Ketoprofen

Ketoprofen (Actron) is a non-selective NSAID exhibiting IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. It is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes reversibly, which decreases production of pro-inflammatory prostaglandin precursors. Based on in vitro IC (50) COX-1:IC (50) COX-2 ratios, robenacoxib was COX-2 selective (ratio=32.2), diclofenac (ratio=3.9) and meloxicam (ratio=2.7) were only weakly COX-2 preferential, and ketoprofen (ratio=0.049) was COX-1 selective.