K145 hydrochloride

K145 hydrochloride accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2 by using human leukemia U937 cells in vitro studies. K145 hydrochloride exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of down-stream ERK and Akt signaling pathways. K145 hydrochloride significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration, thus demonstrating its in vivo efficacy as a potential lead anticancer agent. The antitumor activity of K145 was also confirmed in a syngeneic mouse model by implanting murine breast cancer JC cells in BALB/c mice.