JW55

JW 55 efficacy causes stabilization of Axin2 . JW 55 also decreases canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW 55 inhibits the β-catenin signaling pathway. It Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; JW 55 reduces cell cycle progression and proliferation in SW480 cells in vitro.