JNJ-38877605
Chemical Compounds
- 貨號 Cat. No.
- M1793
- 規格 Size
- 10mg,50mg,100mg
- 品牌 Brand
- No Brand
Description
JNJ-38877605 is a small-molecule, ATP-competitive inhibitor of the catalytic activity of c-Met. JNJ-38877605 showed f600-fold selectivity for c-Met compared with a panel of f250 diverse tyrosine and serine-threonine kinases and was found to potently inhibit HGF-stimulated and constitutively activated c-Met phosphorylation in vitro. In addition, JNJ-38877605 induces regression of U87-MG xenografts in vivo.
