JAK3 (5H2) Antibody

JAK3 (Janus kinase 3) is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this protein are associated with autosomal SCID (severe combined immunodeficiency disease).