Antibodies
IWR-1-endo
- 貨號 Cat. No.
- S7086
- 規格 Size
- 10mgã€25mg
- 品牌 Brand
- Selleckchem
Description
IWR-1-endo
Catalog No.S7086
IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. | |||||
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| Targets | Wnt | |||||
| IC50 | 180 nM [1] | |||||
| In vitro | Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.[1] | |||||
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| Features | ||||||
Protocol(Only for Reference)
References
Chemical Information
| Molecular Weight (MW) | 409.44 |
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| Formula | C25H19N3O3 |
| CAS No. | 1127442-82-3 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | IWR-1 |
| Solubility (25°C) * | In vitro | DMSO | 30 mg/mL (73 mM) |
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| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-, rel- |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
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| Mass(mg) | 0.40944 | 4.0944 | 8.1888 | 12.2832 |
