Antibodies
IWP-L6
- 貨號 Cat. No.
- S7301
- 規格 Size
- 10mgã€50mg
- 品牌 Brand
- Selleckchem
Description
IWP-L6
Catalog No.S7301
IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. | |||||
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| Targets | Porcn | |||||
| IC50 | 0.5 nM (EC50) [1] | |||||
| In vitro | IWP-L6 blocks the phosphorylation of the cytoplasmic Wnt pathway effector Dvl2 in HEK293 cells. In cultured embryonic kidneys, IWP-L6 also inhibits Wnt mediated branching morphogenesis by reversibly blocking Wnt signaling. [1] | |||||
| In vivo | IWP-L6 is stable in human plasma over 24 h, while rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions. In embryonic zebrafish, IWP-L6 effectively inhibits posterior axis formation, a Wnt/β-catenin dependent developmental process. [1] | |||||
| Features | ||||||
Protocol(Only for Reference)
Animal Study: [1]
| Animal Models | Zebrafish embryos harboring an mCherry-based reporter of Wnt/β-catenin signaling. |
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| Dosages | ~5 μM |
| Administration |
References
Chemical Information
| Molecular Weight (MW) | 472.58 |
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| Formula | C25H20N4O2S2 |
| CAS No. | 1427782-89-5 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | Porcn Inhibitor III |
| Solubility (25°C) * | In vitro | DMSO | 25 mg/mL heating (52 mM) |
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| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide |
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