ISG15 MaxPab polyclonal
- 貨號 Cat. No.
- AB-I10
- 規格 Size
- 100 μg
- 品牌 Brand
- Boston Biochem
Description
ISG15 MaxPab polyclonal
rabbit polyclonal
Product Information
100 μg
Use & Storage
Catalog #: AB-I10
ISG15 MaxPab polyclonal
Product Source:
rabbit polyclonal
The ubiquitin-like ISG15 (UCRP) acts similar to ubiquitin and is conjugated to intracellular target proteins. This pathway is distinct from that of ubiquitination with different substrate specificity and interaction with ligating enzymes. ISG15 becomes conjugated to a diverse set of proteins after IFN-α/β stimulation or microbial challenge. The functions or biochemical consequences of ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation. ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. It may also serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments; and may also be involved in autocrine, paracrine and endocrine mechanisms.
Product Information
Quantity:
100 μg
Stock:
100 μg in PBS
Host:
Rabbit
Immunogen:
ISG15 (NP_003326) 1 ~ 165 a.a) full- length recombinant protein with GST tag.
Isotype:
MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPS
GVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRLTQ
TVAHLKQQVSGLEGVQDDLFWLTFEKPLEDQLPLGEYGLKPLSTVFMNLRLRG
GGTEPGGRS
Reactivity:
Human. Other species not tested.
Western Blot Data:
Use & Storage
Use:
Western blotting. Investigator should empirically determine optimal working dilutions. Other applications have not yet been tested.
Storage:
Store at -20oC or -80oC. Aliquot to avoid freeze-thaw cycles.