IRAK-2 Polyclonal Antibody
- 貨號 Cat. No.
- 3220-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= /nbsp;/p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 574 of human IRAK2/p
pbFORMULATION: /b100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-IRAK2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSPECIES REACTIVITY: /bhuman/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For optimal storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bThe pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RacP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF?B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF?B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-?B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis at 1 ug/ml. However, the optimal conditions should be determined individually./p
pbSPECIFICITY: /bDetects a 65 kDa human IRAK2 by Western blotting. K562 cell lysate can be used as a positive control. The antibody has no cross reactivity to IRAK./p
pbFor research use only! Not to be used in humans. /b/p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 574 of human IRAK2/p
pbFORMULATION: /b100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-IRAK2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSPECIES REACTIVITY: /bhuman/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For optimal storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bThe pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RacP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF?B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF?B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-?B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis at 1 ug/ml. However, the optimal conditions should be determined individually./p
pbSPECIFICITY: /bDetects a 65 kDa human IRAK2 by Western blotting. K562 cell lysate can be used as a positive control. The antibody has no cross reactivity to IRAK./p
pbFor research use only! Not to be used in humans. /b/p