Ionomycin
- 貨號 Cat. No.
- I-700
- 規格 Size
- 10 x 100 mg 1mg 5x1mg
Description
Ionomycin
Streptomyces conglobatus
(Ca2+ Salt)
| Product#: | I-700 |
| Sizes: |
| 10 x 100 mg |
| 1 mg |
| 5 x 1 mg |
| M.W.: | 747.08 |
| CAS No.: | [56092-81-0] |
| Structure: |
 |
| Purity: | >98% |
| Bioassay: |
| Ionomycin induced cytosolic Ca2+ increase. Ca2+ traces from Fluo-3 AM loaded C6 glioma cells treated with 1mM Ionomycin. |
 |
| References: |
1. | Liu, W.C. et al. (1978) J. Antibiot. (Tokyo) 31, 815. |
2. | Liu, C.M. et al. (1978) J. Biol. Chem. 253, 5892. |
3. | Kauffman, R.F. (1980) J. Biol. Chem. 255, 2735. |
4. | Morgan, A.J. and Jacob, R. (1994) Biochem. J. 300, 665. |
5. | Chatila, T. et al. (1989) The J. of Immunology 143, 41283. |
6. | Takei, N. et al. (1994) Brain Res. 652, 65. |
7. | Aagaard-Tillery, K.M. et al. (1995) J. Immunol. 155, 3297 |
Ionomycin, is a narrow spectrum antibiotic for Gram-positive bacteria, produced by Streptomyces conglobatus. In mammals cells ionomycin acts as a potent and selective Ca2+ionophore, more effective than A23187. The enhancement of Ca2+ influx by Ionomycin, caused by direct stimulation of store-regulated cation entry and not by a direct action at the plasma membrane.1-4 Ionomycin induces hydrolysis of phosphoinositides, activation of PKC in human T cells and apoptosis in various cells lines.5-7