Interleukin-33
- 貨號 Cat. No.
- RCP9416
- 規格 Size
- 100 µg
- 品牌 Brand
- RANDOX-LIFESCIENCES
Description
| Description: | Interleukin 33 (IL-33) is a proimflammatory cytokine belonging to the IL-1 family. IL-33 is cleaved in vivo, generating an N terminal and a C terminal fragment. The C terminal fragment corresponds to the mature IL-33 protein and mediates its biological effect by interacting with the IL-1 receptor, also known as ST2. Binding of mature IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces the production of associated cytokines in particular IL-4, IL-5 and IL-13 causing severe pathological changes in mucosal organs. RANDOX recombinant Interleukin-33 comprises a 159 amino acid fragment (112-270) corresponding to C terminal Interleukin-33 fragment coding sequence and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use. |
| Form: | Liquid |
| Purity: | >95% by SDS-PAGE |
| References: | Schmitz J. et al. (2005), Immunity. 23(5): 479-90. |