Interferon Gamma Protein, Human, Recombinant

IFN gamma, also known as IFNG, is a secreted protein which belongs to
the type I I interferon family. IFN gamma is produced predominantly by
natural killer and natural killer T cells as part of the innate immune
response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells
once antigen-specific immunity develops. IFN gamma has antiviral,
immunoregulatory, and anti-tumor properties. IFNG, in addition to having
antiviral activity, has important immunoregulatory functions, it is a potent
activator of macrophages, and has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of the type I
interferons. The IFNG monomer consists of a core of six α-helices and an
extended unfolded sequence in the C-terminal region. IFN gamma is
critical for innate and adaptive immunity against viral and intracellular
bacterial infections and for tumor control. Aberrant IFN gamma expression
is associated with a number of autoinflammatory and autoimmune diseases.
The importance of IFN gamma in the immune system stems in part from its
ability to inhibit viral replication directly, and most importantly from its
immunostimulatory and immunomodulatory effects. IFNG also promotes
NK cell activity