Influenza A [A/Thailand/1(KAN-1)/2004 (H5N1)] Neuraminidase (NA) Protein, His Tag

Source : 

Influenza A [A/Thailand/1(KAN-1)/2004 (H5N1)] NA, His Tag (H54-V5247) is expressed from human 293 cells (HEK293). It contains AA His 36 - Lys 449 (Accession # H8PF47).

 

Molecule : Neuraminidase (NA)

 

Synonyms : NA,Neuraminidase

 

Format : Powder

 

Category : Viral Proteins

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 46.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 46.1 kDa. The protein migrates as 50-57 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

 

References :

(1) Manz B., et al., 2012, Submitted to the EMBL/GenBank/DDBJ databases.